From the architectural principles of Vitruvius to the more esoteric theories of feng shui, every civilization has developed its own theories around the impact of architecture on health and well-being. It’s common sense: the spaces we inhabit have a significant effect on how we feel, perform, interact, and indeed, heal. Today, a holistic approach embodied by human-centered design that embraces both low-tech methods and new technologies is creating hospitals that heal both body and mind, spaces that prevent loneliness, technology that harnesses data to tackle epidemics, and green spaces that contribute to healthier cities for all citizens.